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Modified amnion-assisted conjunctival epithelial redirection, using vacuum-dried amnion and fibrin glue, may be an effective ocular surface reconstruction technique in managing limbal stem cell deficiency and improving vision. Vacuum-dried amnion provides advantages of easy handling, better transparency and storage at room temperature, while the use of fibrin glue instead of sutures helps shorten intraoperative time and obviates suture-related complications and the need for removal postop, Darre...

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The FDA has accepted a new drug application from Oyster Point Pharma for OC-01, a nasal spray treatment for the signs and symptoms of dry eye disease, according to a press release. The submission for OC-01 (varenicline) is supported by positive safety and efficacy data from the phase 3 ONSET-2, the phase 2b ONSET-1 and the phase 2 MYSTIC clinical trials, in which more than 1,000 patients with dry eye disease demonstrated significantly significant improvement in Schirmers score compared with cont...

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George Marcellino, PhD, vice president of clinical affairs and marketing at Iridex, died unexpectedly on Feb. 10, according to a statement released by the company. Marcellino served on the Iridex board of directors for 3 years before becoming vice president in 2018. Before joining Iridex, Marcellino co-founded OptiMedica, where he led the development of pattern scanning laser photocoagulation for retinal disease treatment and the Catalys femtosecond laser cataract system. He spent more than 35 y...

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Anterior uveitis may be present in a high percentage of patients infected by Zika virus and is often associated with increased IOP, according to a study. Zika virus (ZIKV) infection is transmitted by Aedes mosquitoes. The first cases were reported in Uganda and Tanzania in the late 1940s, and in subsequent years, outbreaks were identified in several other African and Asian nations, Pacific islands and, later, several countries within Latin America and the Caribbean. Ocular manifestations reporte...

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Bio-Tissue can proceed with a phase 2 study investigating morselized cryopreserved amniotic membrane and cryopreserved umbilical cord following clearance from the FDA, according to a press release. TTBT01 is being studied to support regenerative healing in dry eye disease. Because it is a section 351 biologic investigational new drug, TTBT01 will undergo a strict FDA preapproval process involving two randomized phase 3 clinical trials demonstrating safety and efficacy, the release said. Our lead...

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In this video, David Spalton, MD, speaks about a session he co-chaired at the virtual European Society of Cataract and Refractive Surgeons winter meeting, focusing on paramedical support. The growing demands due to the aging of the population, as well as the current pandemic situation, have intensified the adoption of shared care models in the United Kingdom that include not only the involvement of optometrists and orthoptists in clinical tasks, but also the training of nurses to perform YAG cap...

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Survey data show that the symptom burden of thyroid eye disease persists during the chronic phase of the disease, with most patients reporting continued low quality of life even after systemic glucocorticoid therapy or surgery. Although it is widely understood that thyroid eye disease has a significant burden on patients who are in the acute phase, the impact of the disease on patients who have progressed into the chronic phase is less recognized, Kimberly P. Cockerham, MD, FACS, adjunct clinica...

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